| ncRNA name | Ezh2 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | siRNA transfection, chromatin immunoprecipitation (CHIP), immunofluorescence, qPCR, MMP-9 assay, cell apoptosis assay |
| Expression pattern | associated |
| Functional description | Inhibition of Ezh2 attenuated recruitment of both DNA methylating (Dnmt1) and hydroxymethylating (Tet2) enzymes and 5 hydroxymethyl cytosine at the same region of the MMP-9 promoter, and prevented increase in MMP-9 transcription and mitochondrial damage. |
| PubMed ID | 29261844 |
| Year | 2018 |
| Title | Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes. |
| Drug-related ncRNA | NO |
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